Modeling the Effect of VGCC on Cytosolic Calcium Distribution in Nerve Cells
نویسندگان
چکیده
Calcium ion, the second messenger, plays pivotal role in many physiological processes like, contraction, signaling, prolification, etc. [2]. Due to calcium ions, nerve cells are able to move from one cytosole to synapse or other cytosole. A mathematical model is developed in the form of advectiondiffusion equation to study the effect of different physiological parameters like diffusion coefficient, potential difference, flux at boundary, etc. Laplace transform is employed to find the solution. Graphical results are obtained with the help of MATLAB. In present study it is observed that the effect of advection on cytosolic calcium distribution is significant at high speed flux. VGCC also make the significant effect on cytosolic calcium concentration to increase the concentration. Keywords— Advection diffusion, VGCC, Laplace transforms, Nerve cell, Similarity transform
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تاریخ انتشار 2015